gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Localization of language subsystems with MEG and fMRI

Lokalisation von Subsystemen der Sprachverarbeitung mit MEG und fMRI

Meeting Abstract

  • corresponding author P. Grummich - Neurochirurgische Klinik, Universität Erlangen-Nürnberg
  • C. Nimsky - Neurochirurgische Klinik, Universität Erlangen-Nürnberg
  • M. Buchfelder - Neurochirurgische Klinik, Universität Erlangen-Nürnberg
  • O. Ganslandt - Neurochirurgische Klinik, Universität Erlangen-Nürnberg

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocSA.01.01

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter:

Veröffentlicht: 11. April 2007

© 2007 Grummich et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Objective: In this study we attempted the preoperative localization of subsystems of language areas to define a more precise description of the eloquent cortex using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG).

Methods: MEG measurements were carried out with a 2x37 channel biomagnetic system (Magnes II, 4-D Neuroimaging). Localization was performed by 1-dipole fit or beamformer analysis. For fMRI we used a 1.5T MR scanner with echo planar imaging (Sonata, Siemens Medical Solutions) and a block paradigm with 180 measurements in 6 blocks (rest alternating with activation, 25 slices, 3mm thickness & resolution TR=2470, TE=60). 140 patients with tumors neighbouring language areas were examined. During measurement they had to perform verbal tasks. For the MEG measurements two paradigms were performed in each patient, while in fMRI four paradigms were used. Paradigms differ in the extent of grammatical effort and involvement of receptive and expressive language function.

Results: In the frontal lobe above the classical Broca area, three areas are constantly found across all subjects and language tasks. Depending on the kind of language task, certain areas are more accentuated than others inidcating a different role in language processing. One of these areas, the pars triangularis at the top of the gyrus frontalis inferior, seems to be related to grammatical processing. In the temporal lobe at least two areas can be distinguished: One in the sulcus supratemporalis and one at the end of the Sylvian fissure. These areas are in accordance with results found during cortical stimulation by Duffau.

Conclusions: Detailed knowledge about the language processing network allows safer resections and a better understanding of possible neurological dysfunction.