gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

A new experimental model of sinus thrombosis in pigs for MR imaging studies

Ein neues experimentelles Modell zur Sinusvenenthrombose bei Schweinen für MR Untersuchungen

Meeting Abstract

  • corresponding author P. Spangenberg - Neurochirurgische Klinik, Universitätsklinikum RWTH Aachen
  • C.P. Stracke - Klinik für Diagnostische Radiologie, Universitätsklinik RWTH Aachen
  • M. Katoh - Klinik für Diagnostische Radiologie, Universitätsklinik RWTH Aachen
  • E. Spüntrup - Klinik für Diagnostische Radiologie, Universitätsklinik RWTH Aachen

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocP 10.160

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc377.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Spangenberg et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: The aim of this study was to develop an experimental pig model for the induction of a true cerebral sinus thrombosis with human blood clot which impairs the superior sagittal, the transverse sinus and the bridging veins. The model should be appropriate for further MR investigations, and artefacts should be minimized.

Methods: A combined surgical and interventional approach was chosen in six pigs. After skin incision the skull bone was removed in an area of 3 cm2. The superior sagittal sinus was punctured and a coated guide wire was advanced towards the confluens sinuum. Using this guide wire a 4F introducer sheath was inserted. The sinus lumen and control of the access was visualized by direct contrast injection through the sheath using digital subtraction phlebography. A 4mm balloon mounted on a 2 F catheter was inserted through the sheath and pushed towards the torcular herophili. After inflation of the balloon, 4ml of a human blood-thromboplastine mixture were injected. Digital subtraction phlebography and MR imaging were done before and after thrombus induction.

Results: Induction of cerebral sinus thrombosis was successfully achieved in all 6 animals. In every case the thrombosis involved nearly the whole superior sagittal and transverse sinus. Blood flow along the sinus walls and surrounding the thrombus was seen as a typical sign for a fresh thrombosis. In 2 animals, subdural hemmorrhage occured presumingly due to sinus perforation. MR imaging of thrombosed sinus could be easily performed with only slight impairment of image quality in the region of the surgical approach.

Conclusions: We have developed a reliable new pig model for induction of human blood clot sinus thrombosis. MR measurements of clots can be done without significant artefacts.