Artikel
Experimental swine study of the hemodynamic charcteristics of Onyx 18, 20 and 34 as a new liquid embolic agent in the treatment of arteriovenous malformations in humans
Experimentelle Studie an deutschen Landschweinen zur Charakterisierung von Onyx 18,20 und 34 als neues Flüssigembolisat in der Behandlung arteriovenöser Malformationen beim Menschen
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Autoren
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R. Siekmann
- Dep. of Neuroradiology, University of Gießen
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M.C. Heidt
- Dep. of Cardiology and Cardiovascular Surgery, University of Gießen
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S. Schlottmann
- Dep. of Internal Medicine, Veterinary University of Gießen
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C. Leuser
- Dep. of Internal Medicine, Veterinary University of Gießen
| Veröffentlicht: | 8. Mai 2006 |
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Gliederung
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Objective: Even if there is an ever increasing widespread use of Onyx as a liquid embolic agent in the endovascular treatment of AVMs in humans, the hemodynamic characteristics and differences in the use of Onyx 18,10 and 34 has not yet been described. This was the aim of the experimental study on 36 swines, using the rete mirabile as a biological AVM model, which were performed between January and November 2005.
Methods: 42 swines were investigated totally, 6 had to be excluded from data analysis because of death or dissection of the feeding artery of the rete mirabile. Due to an endovascular approach modifying the rete mirabile with an av-shunt from the "arterial" to the "venous" part, the remaining 36 swines werde divided into 18 high flow(>30 ml/min) and 18 low flow (<30 ml/min). These groups were subdivided into 3 groups of Onyx 18,20 and 34 with 6 swines each.
Results: There are differences in the volume and time intervals of adminstration between Onyx 18,20 and 34, as well as the ratio of injection- and breaktimes (standardized as 1 min after reflux) in the embolization of the rete mirabile. The flow rate is an important factor for the volume of Onyx which can be administrated, but seems not to be so important as the differences between the densities of the various Onyx. The data analysis is still in progress.
Conclusions: Experimental data in standardized adminstration of Onyx 18,20 and 34 in high and low flow situations, using the rete mirabile in swines are helpful characterizing the hemodynamic parameters in these substances. The data support the rationale of choosing the best Onyx in the individual treatment of human brain and spinal AVMs.
