gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

Unique chromosomal aberration in a recurrence malignant meningioma

Ungewöhnliche chromosomale Veränderung eines rezidivierenden malignen Meningeoms

Meeting Abstract

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  • corresponding author P. Klawunde - Klinik für Neurochirurgie, Otto-von-Guericke-Universität Magdeburg
  • C. Mawrin - Institut für Neuropathologie, Otto-von-Guericke-Universität Magdeburg
  • A.F. Pelz - Institut für Humangenetik, Otto-von-Guericke-Universität, Magdeburg
  • T. Schneider - Klinik für Neurochirurgie, Otto-von-Guericke-Universität Magdeburg

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocP 06.75

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Veröffentlicht: 8. Mai 2006

© 2006 Klawunde et al.
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Objective: Meningiomas are the second most common symptomatic adult central nervous system tumors, account for approximately 20% of all primary intracranial tumors in adult. Most meningiomas are benign, but approximately 20% display aggressive features, and recurrence rates for atypical and anaplastic meningiomas have been reported from 38-78%. However, it is little known about the genetic events associated with aggressive phenotype in malignant meningiomas. Previous cytogenetic and molecular-cytogenetic studies have shown complex numerical and structural aberrations, which are frequent findings in meningiomas grade II and III. The most commonly observed aberrations in decreasing frequency are monosomy 22 or deletion of 22q, deletions of 14q, 1p, 10q, loss of a sex chromosome, and tetraploid karyotypes. Here we report a case of a recurrence anaplastic meningioma with unique additional chromosomal aberrations.

Methods: This 41-year-old man has been operated seven times for a left parietal anaplastic meningioma within a period of 4 years. Histopathology revealed a malignant meningioma with high mitotic activity. In spite of additional surgery, X-ray treatment, and systemic therapies with 5x ACNU/VM-26 and Hydroxyurea, postoperative follow-up revealed consistently tumor recurrence. Persistent symptomatic seizures are treated with Timonil. For the present investigation, tumor cells derived from fresh surgical specimens were long-term cultured in RPMI medium for conventional chromosome preparation and GTG banding.

Results: We detected 3 different karyotype by conventional cytogenetic analysis (CCA): 1) hypodiploid cells with a loss of the Y chromosome, 2) near-triploid cells with multiple chromosomal aberrations like dicentric chromosome 2, deletion of 3p, additional materials on 4q and 8q, isochromosomes 9q and 17q and a various number of marker chromosomes, 3) near-tetraploid cells with additional materials of 1q and 9p, deletions of 5p and 14q, loss of chromosome 2 and a various number of marker chromosomes.

Conclusions: The investigated malignant meningioma displayed karyotype alterations previously reported for malignant meningiomas, including the 14q aberration and a possible tetraploid karyotype. In addition, a near-triploid karyotype and alterations like 5p-, 8q+ are chromosomal aberrations which has not been reported before to occur in these tumors. Our findings suggest that complex karyotype alterations might be a characteristic feature in malignant meningiomas.