gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

Nicardipine prolonged-release pellets reduce the incidence of cerebral vasospasm following aneurysmal subarachnoid hemorrhage – a prospective, monocentric, double blind study

Nicardipin prolonged-release pellets verringern die Inzidenz des zerebralen Vasospasmus nach aneurysmatischer Subarachnoidalblutung – eine monozentrische, randomisierte, Doppelblind-Studie

Meeting Abstract

  • corresponding author M. Barth - Neurochirurgische Klinik, Mannheim
  • H.-H. Capelle - Neurochirurgische Klinik, Mannheim
  • S. Weidauer - Neuroradiologie, Frankfurt am Main
  • C. Thomé - Neurochirurgische Klinik, Mannheim
  • P. Schmiedek - Neurochirurgische Klinik, Mannheim
  • H. Kasuya - Department of Neurosurgery, Tokyo/Japan
  • P. Vajkoczy - Neurochirurgische Klinik, Mannheim

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocSO.06.06

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc196.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Barth et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objective: This trial investigated the efficacy of Nicardipine prolonged-release implants, placed into the basal cisterns at the time of aneurysm clipping, in patients with aneurysmal subarachnoid hemorrhage (SAH).

Methods: 32 patients were included with severe SAH (H&H grade 3-4, Fisher grade 3). All patients underwent clipping and were randomized into two groups: immediately after clipping of the aneurysm 16 patients received Nicardipine prolonged-release pellets (n=10; 4 mg of Nicardipine per pellet) located in direct contact to the exposed proximal blood vessels (ICA, A1, M1); in 16 control patients the basal cisterns were opened and washed out only, without leaving implants. Investigators and an external neuroradiologist were blinded to the randomization. Degree of vasospasm was measured in relative differences [%] of vessel diameters of the follow-up angiogram on day 8±1 after SAH compared to the baseline angiogram in different basal vessel segments. Primary endpoints were incidence of angiographic vasospasm (<33% constriction) on day 8±1 after SAH and new territorial infarcts on CT.

Results: 29 patients (14 verum, 15 control) were included in the Intent-To-Treat population. Implantation of Nicardipine prolonged-release pellets yielded a significant reduction in the incidence of angiographic vasospasm: while 75% of the control patients demonstrated spasm of the basal arteries, only 7% did so in the pellet group. The incidence of new territorial infarcts in the control and pellet groups was 47% and 7%, respectively. There was no adverse event pattern indicating a toxicity of the implants.

Conclusions: This study indicates that Nicardipine prolonged-release implants reduce the incidence of cerebral vasospasm and infarcts following severe aneurysmal SAH.