gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

Safety margins in fiber tract navigation

Sicherheitsabstände in der Navigation von Bahnsystemen

Meeting Abstract

  • corresponding author C. Nimsky - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen
  • O. Ganslandt - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen
  • F. Enders - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen
  • A. Boosz - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen
  • R. Fahlbusch - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen
  • M. Buchfelder - Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Erlangen

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocSA.03.06

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc100.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Nimsky et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objective: To determine the relationship of the distance of a tumor to the pyramidal tract in respect to neurological outcome of surgery of intracranial lesions and to visualize hulls representing safety margins around the pyramidal tract for integration into a navigation system.

Methods: In 64 patients (37 f, 27 m) with intracerebral lesions (52 gliomas, 6 cavernomas, 6 other) adjacent to the pyramidal tract, diffusion tensor imaging (DTI) data were integrated in a navigational setup. Diffusion data (b=0) were rigidly registered with standard T1-weighted 3-D images. Fiber tracking was performed applying a tensor-defection algorithm using a multiple volume of interest approach as seed regions for tracking. fMRI data identifying the motor gyrus were applied as selection criteria to define the fibers of interest. After tracking, a 3-D object was generated representing the pyramidal tract. Additionally, hulls wrapping all fiber structures representing safety margins were visualized. The minimum distance of the pyramidal tract to the lesion was measured in the 3-D space.

Results: In all patients the pyramidal tract could be visualized in the operative field by applying the heads-up display of the operating microscope. In 7 patients (11%) a new or worsened postoperative paresis was seen, which was transient in 5 of them; thus, in only 2 patients (3,1%) was there a new permanent neurological deficit. 6 of these patients were in the group where the pyramidal tract reached the lesion (total n=33). The risk for an at least transient postoperative deficit was: 18.2%, 14.3%, 0%, and 0% respectively in the groups with a distance of the pyramidal tract to the lesion of: 0, 0-5, 5-10, and >10 mm. These safety margins could be visualized by additional hulls wrapping the fibers of the pyramidal tract.

Conclusions: DTI fiber tracking data can be reliably integrated into navigational systems providing an intraoperative visualization of the pyramidal tract. A safety margin representing the critical distance of 5 mm around the pyramidal tract is visualized by wrapping hulls. This technique allowed the resection of lesions adjacent to the pyramidal tract with a low morbidity.