gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

Clusters of spreading depression is an electrophysiological correlate of delayed neurological deterioration after subarachnoid hemorrhage

Spreading-Depression-Clusters sind elektrophysiologische Korrelate für verzögerte neurologische Defizite nach Subarachnoidalblutung

Meeting Abstract

  • corresponding author J.P. Dreier - Charité-Berlin, Klinik für Neurologie, Berlin
  • J. Woitzik - Universitätsklinikum Mannheim, Klinik für Neurochirurgie, Mannheim
  • M. Fabricius - University of Copenhagen, Department of Neurophysiology, Copenhagen, Denmark
  • R. Bhatia - King’s College, London, UK
  • S. Major - Charité-Berlin, Klinik für Neurologie, Berlin
  • C. Drenckhahn - Charité-Berlin, Klinik für Neurologie, Berlin
  • T.N. Lehmann - Charité–Berlin, Klinik für Neurochirurgie, Berlin
  • A. Sarrafzadeh - Charité–Berlin, Klinik für Neurochirurgie, Berlin
  • COSBID study group
  • M. Lauritzen - University of Copenhagen, Department of Neurophysiology, Copenhagen, Denmark
  • A.J. Strong - King’s College, London, UK

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocFR.10.09

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc067.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Dreier et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Aneurysmal subarachnoid hemorrhage (SAH) has a mortality rate around 45%. Delayed ischemic neurological deficit (DIND) is the predominant in-hospital complication. In animal experiments it was found that products of hemolysis in the subarachnoid space induced prolonged cortical spreading depressions (SD) which triggered waves of severe vaso-constriction. This process led to widespread cortical necrosis similar to the predominant infarct pattern of DIND in human autopsy studies. Therefore, we prospectively studied the occurrence of SD in patients with SAH.

Methods: 18 patients were consecutively recruited by four centers, members of the Co-operative Study on Brain Injury Depolarizations (COSBID) study group. Research consents were obtained after clinical decision for surgical treatment. A linear, 6-contact electrocorticography (ECoG) recording strip (Wyler) was placed on the cortex accessible through the craniotomy. Thereafter, the electrocorticogram was continuously monitored for periods up to 10 days. SD was defined by the sequential onset of a rapidly developing reduction of the power of ECoG amplitude of at least 50% associated with a propagating, polyphasic slow potential shift.

Results: During a recording period of 2265.5 hours 13 of 18 patients developed a total of 298 SD. Six patients showed a delayed decrease of consciousness (GCS, fall from GCS 14 (12, 15) to 9 (8, 11), P<0.05, Wilcoxon test). This correlated significantly with the occurrence of new clusters of SD. Evolution of new CT-proven brain infarcts was characterized by a pattern change of SD towards very prolonged depression.

Conclusions: 72% of patients with SAH in this study showed recurrent SD. Delayed neurological deterioration was associated with new clusters of SD. Brain infarcts were associated with a characteristic pattern change of SD.