gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Changes of coagulation parameters during surgery of meningiomas

Änderung der Gerinnungsparameter während der operativen Versorgung intrazerebraler Meningeome

Meeting Abstract

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  • corresponding author P. Tanner - Neurochirurgische Klinik und Poliklinik, Klinikum Großhadern, Ludwig-Maximilians-Universität München
  • R. Cincu - Neurochirurgische Klinik und Poliklinik, Klinikum Großhadern, Ludwig-Maximilians-Universität München
  • E. Uhl - Neurochirurgische Klinik und Poliklinik, Klinikum Großhadern, Ludwig-Maximilians-Universität München

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP126

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0394.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Tanner et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Surgery of meningiomas has been reported to be associated with changes of the coagulation system. An increase of D-dimers has been described and was associated with an increased risk for thromboembolism. Aim of the current study was to investigate changes of the coagulation parameters with regard to intraoperative blood loss.

Methods

In this prospective study, the measurement of D-dimers, fibrinogen and AT III was added to the routine pre-, intra- and postoperative evaluation of standard coagulation parameters (PTT and aPTT) in patients undergoing surgical removal of intracranial meningiomas. Hemoglobin, platelets, coagulation parameters, tumor volume and duration of surgery were correlated to the intraoperative blood loss.

Results

Data were available for 52 patients undergoing surgical removal of intracranial meningiomas. Mean (SD) age of the patients was 56(14) years. Median tumor volume was 67cm3. Mean blood loss during surgery was 742± 858ml (range 50 – 5500ml). Hb decreased from 14.1± to 10.1 until the end of surgery. Median D-dimer (µl/ml) increased from 0.3 before surgery to 2.1 intraoperatively and to 2.5 postoperatively. Fibrinogen levels (mg/dl) were 291 and decreased to 157 during surgery, AT III from 109% to 78%. Preoperative and intraoperative coagulation parameters revealed only weak correlation to the amount of total blood loss with aPTT showing the highest correlation (r=0.6, p<0.01).

Conclusions

Our preliminary evaluation show that routine preoperative coagulation parameters do not correlate with intraoperative blood loss. Additional measurement of D-dimer, fibrinogen and AT III before and during surgery yield no further information on disturbances of hemostasis neither before nor during surgery.