gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Predictive value of p(ti)O2 and EEG monitoring as outcome measure in a rodent mass lesion model

Prediktiver Wert des p(ti)O2 und EEG Monitorings für das Outcome nach fokaler Hirnläsion bei der Ratte

Meeting Abstract

  • corresponding author R. Burger - Klinik für Neurochirurgie, Universität Regensburg
  • E.-M. Stoerr - Klinik für Neurochirurgie, Universität Regensburg
  • T. Finkenzeller - Klinik für Radiologie, Universität Regensburg
  • J. Warnat - Klinik für Neurochirurgie, Universität Regensburg
  • A. Brawanski - Klinik für Neurochirurgie, Universität Regensburg

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP058

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0326.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Burger et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Predictive value of brain p(ti)O2 and EEG monitoring on a 2 week assessment of behavorial deficits after a focal mass lesion model in rodents.

Methods

25 Spraque Dawley rats were included (224±17g) in the study. Complete monitoring was able in 18/25 and long-term neurobehavioral testing in 13/18 animals. Baseline measurement (60±3min) of brain partial oxygen pressure [p(ti)O2] and EEG (visual inspection scale, 1=isoelectric, 5=good) was followed by induction of an epidural focal mass lesion with a balloon. The endpoint of balloon inflation was defined by flattening of the EEG. The mass lesion was prolonged over 60 min. After reperfusion animals were followed over 61±3 min before animals were extubated and brought back to their cages. Posttraumatic mortality was evaluated and neurobehavior assessed over 14 days [beam balance (BB); beam walking (BW); open field (OF); postural reflex (PR); Morris water maze (MWM). The lesion was also evaluated by MRI and histology.

Results

Intraischemic p(ti)O2 values at the end of prolonged brain compression in deceased animals were lower (2.8±2.5mmHg) compared to surviving animals (10±7mmHg, p=0.016) and corresponded with EEG inpections scores in both groups (p=0.03). After 60 min of reperfusion p(ti)O2 did not differ between deceased and surviving animals (p=0.821, 23±6 mmHg versus 24±8 mmHg) while EEG activity was significantly depressed in deceased compared to surviving animals (p=0.003; 1.8±0.8/ 4.4±1). In animals which survived p(ti)O2 and EEG scoring values at 60 min of prolonged balloon compression and after reperfusion did not correlate with individual neurobehavior 14 days after the trauma.

Conclusions

Intraischemic p(ti)O2 and intraischemic and acute postischemic EEG monitoring predict fatal outcome. Long-term neurobehavior did not correlate with individual results during neuromonitoring.