Artikel
Microelectrode recordings of the subthalamic nucleus in DBS surgery
Mikroelektrodenableitungen des Nucleus subthalamicus im Rahmen der tiefen Hirnstimulation
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Autoren
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S. Breit
- Hertie-Institute for Clinical Brain Research, University of Tübingen
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R. Popa
- Hertie-Institute for Clinical Brain Research, University of Tübingen
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M. Tatagiba
- Dept. of Neurosurgery, University of Tübingen
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T. Gasser
- Hertie-Institute for Clinical Brain Research, University of Tübingen
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D. Freudenstein
- Dept. of Neurosurgery, University of Tübingen
| Veröffentlicht: | 4. Mai 2005 |
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Gliederung
Text
Objective
In recent years deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for the treatment of advanced Parkinson’s disease (PD), leading to striking improvements in motor function and quality of life. The clinical outcome largely depends on the accuracy of targeting, which should not rely on imaging based preoperative targeting alone, but also on intraoperative test stimulation and electrophysiological exploration by microelectrode recordings. In this study we describe our experience with intraoperative microelectrode recordings and present the electrophysiological characteristics of STN neurons.
Methods
Twenty-two patients with idiopathic PD underwent simultaneous, bilateral DBS electrode implantation into the STN. In all patients, microelectrode recordings were performed intraoperatively. Extracellular single unit activity was analysed offline. Mean firing rate, firing pattern and interspike interval coefficient of variation were determined for all recorded neurons.
Results
STN neurons had a mean firing rate of 27.6±14.3 spikes/s (mean ±SD, n=453). The majority of neurons displayed a random or bursting firing pattern with a mean interspike interval coefficient of variation of 1.70±0.76. The average maximal trajectory length within STN was 4.2 mm.
Conclusions
According to the results of our study, the identification of the borders of the STN by microelectrode recordings could be achieved on a routine basis intraoperatively, thus increasing the accuracy of STN targeting.
