gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

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Focal cortical dysplasias: surgical outcome in 67 patients in relation to histological subtypes and dual pathology

Fokale kortikale Dysplasien: Chirurgisches Outcome bei 67 Patienten in Abhängigkeit des histologischen Subtyps und einer dualen Pathologie

Meeting Abstract

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  • corresponding author S. Fauser - Epilepsy Center, University of Freiburg
  • A. Schulze-Bonhage - Epilepsy Center, University of Freiburg
  • J. Honegger - Department of Neurosurgery, University of Freiburg
  • H. Carmona - Department of Neurosurgery, University of Freiburg
  • S. Rona - Epilepsy Center, University of Freiburg
  • H. J. Huppertz - Epilepsy Center, University of Freiburg
  • T. Bast - Department of Child Neurology, University of Heidelberg
  • K. Strobl - Epilepsy Center Kork, Kehl
  • G. Pantazis - Department of Neuropathology, University of Freiburg
  • B. J. Steinhoff - Epilepsy Center Kork, Kehl
  • R. Korinthenberg - Department of Neuropediatrics and Muscular Diseases, University of Freiburg
  • D. Rating - Department of Child Neurology, University of Heidelberg
  • B. Volk - Department of Neuropathology, University of Freiburg
  • J. Zentner - Department of Neurosurgery, University of Freiburg

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP012

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0280.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Fauser et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Objective

In this study the impact of histological subtypes and of dual pathology on the surgical outcome in patients with intractable epilepsy due to focal cortical dysplasia (FCD) was investigated.

Methods

67 patients with FCD underwent retrospective analysis at follow-up periods of 6 to 48 months after epilepsy surgery. Histological subtypes were classified according to Palmini, and seizure outcome according to Engel.

Results

Considering outcome at the last follow-up, Engel Ia was achieved in 63% of patients with mild malformation of cortical development, 67% with FCD1a, 55% with FCD1b, 43% with FCD2a, and 50% with FCD2b. Considering outcome at follow-up periods over 12 and 24 months, Engel Ia was achieved in significantly more patients with FCD1 than with FCD2, and Engel IV occurred most frequently in patients with FCD2a. Outcome in patients with dual pathology was favourable (66% Engel Ia). In all subgroups, no relevant change in outcome was observed over time.

Conclusions

In conclusion, although a predominantly temporal localization of FCD1 may have played a role, a similarly better outcome in FCD1 was also observed in extratemporal epilepsy, suggesting that the histological subtype is at least a cofactor which may influence the postsurgical outcome.