gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Deep brain stimulation of the VIM for tremor in multiple sclerosis

Tiefe Hirnstimulation des VIM bei MS-Tremor Patienten

Meeting Abstract

  • corresponding author M. O. Pinsker - Department of Neurosurgery, University Medical Center of Schleswig-Holstein, Campus Kiel
  • R. U. Stiller - Department of Neurosurgery, University Medical Center of Schleswig-Holstein, Campus Kiel
  • J. Herzog - Department of Neurology, University Medical Center of Schleswig-Holstein, Campus Kiel
  • J. Volkmann - Department of Neurology, University Medical Center of Schleswig-Holstein, Campus Kiel
  • H. M. Mehdorn - Department of Neurosurgery, University Medical Center of Schleswig-Holstein, Campus Kiel

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc11.05.-10.11

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0225.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Pinsker et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

We report on our experiences with deep brain stimulation of the VIM for disabling tremor in patients with multiple sclerosis.

Methods

Ten patients with multiple sclerosis (mostly chronic progressive course) underwent implantation of DBS electrodes into the VIM from 2001 to 2004. In all cases intraoperative microelectrode recording and macrostimulation was performed under local anaesthesia before permanent implantation.

Results

Implantation was bilateral in five patients and unilateral also in five patients. The Fahn Tremor score preoperatively was in mean 74, 46 at 3-months and 51 at 12-months. In those patients with a longer follow-up (up to 36 months) there was no clinical deterioration up to now. According to results of macrostimulation and microelectrode recording the most permanent electrodes were implanted on the medial trajectory (n=11) and the central trajectory (n=4). Best stimulation effects were on the two lower contacts, i.e. in the medio-caudal portion of the VIM. There was one intracerebral haemorrhage with a transient hemiparesis, which resolved completely after three months.

Conclusions

Thalamic stimulation significantly reduced tremor associated with MS and improved the hand function of the targeted upper limb. The best stimulation results were achieved on the lowest two contacts of the medial and, less frequently, of the central trajectory.