gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Presurgical language fMRI in children and adolescents

Prächirurgisches Sprach-fMRT bei Kindern und Jugendlichen

Meeting Abstract

  • J. Spreer - Neuroradiology, University Freiburg
  • R. Schwarzwald - Neuroradiology, University Freiburg
  • M. Garcia-Alzamora - Neuroradiology, University Freiburg
  • S. Rona - Epileptology, University Freiburg
  • A. Schulze-Bonhage - Epileptology, University Freiburg
  • U. Hubbe - Neurosurgery, University Freiburg
  • corresponding author V. Van Velthoven - Neurosurgery, University Freiburg
  • A. Quiske - Epileptology, University Freiburg

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc11.05.-08.07

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2005/05dgnc0210.shtml

Veröffentlicht: 4. Mai 2005

© 2005 Spreer et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Determination of the cerebral language representation is an essential step in the presurgical diagnostic work-up of epilepsy patients. Invasive procedures as the intracarotid amytal-test are increasingly replaced by non-invasive functional magnetic resonance imaging (fMRI). However, fMRI requires cooperation of the patients and reports on the application of this method in paediatric patients are scarce. We retrospectively reviewed the language fMRI studies of the last 4 years in order to evaluate the usefulness of clinical language fMRI studies in children and adolescents.

Methods

In the period from 12/1999 until 12/2004 in our department 247 clinical language fMRI studies were performed. In 52 studies the patients were younger than 18 years (13x 6 to 10 y., 25x 11 to 15 y., 14x 16 or 17 y.). Most patients were candidates for epilepsy surgery. FMRI was performed on a 1.5T scanner with multislice gradient echo EPI sequences. Different language paradigms requiring semantic decisions and/or covert language production were used. Stimuli were presented visually or acoustically. Data evaluation included motion correction, spatial and temporal smoothing, and a correlation analysis. "Activated" voxels (r>0.5) were colour-coded and superimposed onto anatomical T1-weighted images.

Results

In the youngest age group (<10 y.) 6/13 studies (46%) were non-diagnostic, in the majority of cases due to movement artefacts. In two patients a diagnostic result could be obtained in a second fMRI after several months. In the older children (11 to 15 y.) 6/25 (24%), and in the adolescents (16 to 18 y.) 2/13 (15%) of the fMRI studies were non-diagnostic. The best results concerning lateralisation were obtained with visually presented paradigms in all age groups.

Conclusions

Even in 6 to 10 years old children a successful determination of the cerebral language representation by fMRI was possible in the majority of our cases, although, as expected, in younger children the number of drop outs due to movement artefacts was higher than in older children and adolescents. Thus, in the diagnosis of the cerebral language representation fMRI should be the procedure of first choice in all age groups.