gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

Meningioma – Is there an association with human leukocyte antigens (HLA)

Untersuchungen zur HLA-Assoziation von zerebralen Meningeomen

Meeting Abstract

  • corresponding author Michail Tschigrjai - Interbranch HLA Laboratory / Department GHATT, Institute of Medical Immunology, Martin-Luther University, Halle/Saale; Klinik für Neurochirurgie, Saarbrücken
  • H. K. G. Machulla - Interbranch HLA Laboratory / Department GHATT, Institute of Medical Immunology, Martin-Luther University, Halle/Saale
  • A. Schaff - Interbranch HLA Laboratory / Department GHATT, Institute of Medical Immunology, Martin-Luther University, Halle/Saale
  • N. G. Rainov - Department of Neurological Sciences, University of Liverpool, Liverpool /UK

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 06.54

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2004/04dgnc0337.shtml

Veröffentlicht: 23. April 2004

© 2004 Tschigrjai et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

The expression of HLA alleles plays an important role in the development and recurrence of benign and malignant diseases. Association of single HLA alleles or haplotypes with neoplastic processes has been investigated previously, and correlation between HLA and solid tumors, such as head and neck cancers or uterine cervical squamous epithelial lesions, were reported. However, there is no published data on the influence of the HLA system on the development of symptomatic cerebral meningioma, a mostly benign intracranial tumor of mesenchymal origin in adults. The aim of the present study was to find out correlations between HLA markers and meningioma as a further brain tumor.

Methods

The present investigation is comparing the incidence of single HLA alleles and haplotypes in 81 adult Caucasian patients with symptomatic CNS meningiomas to that of 157 area- and race-matched healthy controls. Both standard serologic and molecular genetic (PCR) techniques were used for HLA typing.

Results

Our results suggest an association between single HLA alleles and occurrence of clinically symptomatic meningioma. Patients with HLA-A*02 had a 2.5-fold increased risk of meningioma (p=0.02), and those with HLA-DQB1*05 a 1.8-fold increased risk of meningioma (p=0.05). Conversely, HLA-A*01, -B*08 and -DRB1*03 were associated with a 0.4-, 0.5-, and 0.5-fold, respectively, decreased risk of meningioma (p=0.008; p=0.05, and p=0.04). Moreover, the occurrence rate of combinations and estimated haplotypes containing the above HLA alleles was strikingly different in meningioma patients compared with controls: significantly increased for the haplotypes HLA-A*02:DRB1*04 (p=0.02, RR=2.5) and HLA-A*02:DRB1*04:DQB1*0302,DQB1*05 (p=0.03, RR=7.5), and significantly decreased for the haplotype HLA-A*01:B*08:DRB1*03 (p=0.01, RR=0.2).

Conclusions

In conclusion, these data suggest that some single HLA alleles and haplotypes may protect from or predispose to developing symptomatic CNS meningioma during adult life. These associations may be indicative of the involvement of the immune system in the host antitumor surveillance, recognition, and destruction of de novo arising human tumor cells.