gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

A novel dynamic model for experimental spinal cord compression

Ein neues dynamisches Modell zur experimentellen Rückenmarkskompression

Meeting Abstract

Suche in Medline nach

  • corresponding author Gerhard Marquardt - Klinik für Neurochirurgie Johann-Wolfgang-Goethe-Universität, Frankfurt/Main
  • M. Setzer - Klinik für Neurochirurgie Johann-Wolfgang-Goethe-Universität, Frankfurt/Main
  • V. Seifert - Klinik für Neurochirurgie Johann-Wolfgang-Goethe-Universität, Frankfurt/Main

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 02.20

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2004/04dgnc0303.shtml

Veröffentlicht: 23. April 2004

© 2004 Marquardt et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

To present a novel dynamic model for experimental spinal cord compression.

Methods

The spine is exposed in the midthoracic level via a dorsal approach. On each side of one vertebral lamina, a small hole is countersunk caudal of the articular process. A silicon band is passed through these holes resulting in formation of a loop. The spinal dura is exposed performing an interlaminar approach and by gently pulling at the ends of the band the loop is brought in contact with the dura. The ends of the band are passed through rubber tubes on both sides and a hemoclip is attached to the band. Thus the loop is fixed in its position encircling 270° of the circumference of the spinal cord. Subsequently the loop is gradually tightened by pulling at the ends of the bands and fixing it again in its new position. In doing so the spinal cord is increasingly compressed in a dynamic manner. Decompression of the spinal cord is easily achieved by cutting one band and removing the whole device.

Results

This new model was established in 30 white rabbits, and it was feasible to create reproducible progressive neurological deficits in all animals. The compressive effect of the loop is impressively presented using MRI. The severity of the paresis depended on the degree and duration of compression. Decompressing the spinal cord, the neurological deficits were reversible in the majority of animals. In those animals who did not recover subsequent MRI revealed the occurrence of chronic myelopathy.

Conclusions

This novel model features reproducibility of paresis and neurological recovery. Since it is a dynamic model, and rate and degree of compression can be chosen arbitrarily, it can be used for acute, subacute, and chronic spinal cord compression in equal measure.