gms | German Medical Science

126. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

28.04. - 01.05.2009, München

Preoperative FDG-PET-CT correlates with intraoperative findings in patients with peritoneal carcinomatosis

Meeting Abstract

  • I. Königsrainer - General, Visceral- and Transplant Surgery, Tübingen, Germany
  • D. Zieker - General, Visceral- and Transplant Surgery, Tübingen, Germany
  • P. Aschoff - Radiology
  • S. Beckert - General, Visceral- and Transplant Surgery, Tübingen, Germany
  • J. Hartmann - Oncology
  • C. Pfannenberg - Radiology
  • F. Fend - Pathology
  • corresponding author B.L. Brücher - General, Visceral- and Transplant Surgery, Tübingen, Germany
  • A. Königsrainer - General, Visceral- and Transplant Surgery, Tübingen, Germany

Deutsche Gesellschaft für Chirurgie. 126. Kongress der Deutschen Gesellschaft für Chirurgie. München, 28.04.-01.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09dgch11665

DOI: 10.3205/09dgch553, URN: urn:nbn:de:0183-09dgch5536

Veröffentlicht: 23. April 2009

© 2009 Königsrainer et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction: Peritoneal carcinomatosis until recently were considered incurable. Interdisciplinary multimodal therapy including extensive cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) offers significant survival benefit. So far, no radiomorphological imaging can predict the intraoperative tumor load. Combined FDG-PET-CT-scan might offer an impact on patient selection, because its findings might influence making the decision for peritonectomy and HIPEC. We evaluated the results of preoperative FDG-PET-CT-scan by correlating the findings of metabolic imaging with the intraoperative findings of patients who underwent peritonectomy and HIPEC.

Material and methods: Eleven consecutive patients (mean age: 61,45years) underwent preoperative FDG-PET-scans, followed by cytoreductive surgery and HIPEC. The intraperitoneal tumor load was assessed preoperatively by FDG-PET-CT-scan according to the Peritoneal-Carcinomatosis-Index (PCI-PET-CT) according to the intraoperative PCI reported by Sugarbaker (PCI-Sugarbaker). Both indices (PCI-PET-CT and PCI-Sugarbaker) underwent correlation analysis. Moreover we divided the abdominal quadrants into 4 regions (1: upper abdomen, 2: middle abdomen, 3: lower abdomen-pelvis, 4: intestine including jejunum and ileum) and correlated again the different regions.

Results: The PCI-PET-CT (mean: 20,54+/- 12,18) was statistically significant correlated with the PCI-Sugarbaker (mean: 21,09+/- 12,8) (r2= 0.929; p<0.0001). In addition, this correlation could be found in respect to the 4 PCI subgroups (upper abdomen: r2=0.765; p=0.006; middle abdomen: r2=0.779; p=0.005; lower abdomen-pelvis: r2=0.746; p=0.008 and intestine: r2=0.862; p=0.001).

Conclusion: The PCI-FDG-PET-CT correlates well with the intraoperative Peritoneal-Carcinomatosis-Index by Sugarbaker. Further studies are warranted investigating the potential impact of FDG-PET-CT on preoperative patient selection for peritonectomy and HIPEC in patients suffering from peritoneal carcinomatosis.